My little brother has Down syndrome. He's nine years old (wow, time flies); ten years younger than me.
When he smiles, it's like the whole room instantly lights up. He can melt anyone's heart; he's absolutely adorable. Very huggy and loving, too, and not shy at all.
He tries to talk, but his speech comes out garbled. The doctors thought it might be because of fluid in his ears muffling sound he heard and therefore making sounds harder to reproduce correctly, so he now has tubes in his ears. They help a little, but he's not good with putting words together and enunciating them correctly. Mostly it's just one-word questions or answers (a lot of "No!"

). His fine motor functions are slow to develop (meaning he can't write legibly at this point), and his eyes have trouble focusing (they cross a lot). He's had one or two surgeries on his eyes but they didn't help much, and he refuses to wear his glasses.

His mind probably won't ever develop beyond that of a five or ten-year-old. He won't be able to live on his own or drive a car, and he'll probably never have a "real" job.
Down syndrome (or Down's syndrome, as named after John Langdon Down, the British physician who described the syndrome in 1866) *is a chromosomal condition caused by the presence of all or part of a third copy of chromosome 21. Down syndrome is the most common chromosome abnormality in humans. It is typically associated with a delay in cognitive ability (mental retardation, or MR) and physical growth, and a particular set of facial characteristics. The average IQ of young adults with Down syndrome is around 50, compared to children without the condition with an IQ of 100. (MR has historically been defined as an IQ below 70.) A large proportion of individuals with Down syndrome have a severe degree of intellectual disability.*
It's characterized by a certain set of facial features (almond-shaped eyes being the most recognizable).
There are different types and degrees of Down syndrome. Every case is unique and special.

*information between asterisks above copied from
http://en.wikipedia.org/wiki/Down_syndrome *